Today’s post is going to be about a little gem I received in my most recent Powder City grab bag of new things to explore. It looks to be useful, but like the previous one on PEA and Hordenine, it still needs some experimenting and research. However, I find that I am enjoying it so far.
What is Sulbutiamine?
Sulbutiamine is well-known among drug and supplement nerds but is often overlooked.
For one, it’s a derivative of vitamin B1, Thiamine. Two variant thiamine molecules hang out together, and they become the lipophilic sulbutiamine:
Sounds ordinary enough, right? Well, the lipophilic (but still water-soluble) properties of sulbutiamine make it an interesting substance and I’ll touch upon why in a moment.
Where can I get Sulbutiamine?
Most of the modern nootropic/bulk supplement stores sell it. I got mine from Powder City.
Effects, Method of Action and Benefits of Sulbutiamine
What sets sulbutiamine apart from plain old Vitamin B1 is the fact that it’s lipophilic (oil or fat-soluble). Because of its lipophilic properties, it is able to cross the blood-brain barrier to directly affect the brain.
Nootropic nerds like Sulbutiamine because of its effects on the dopaminergic system. Reportedly it can upregulate dopamine receptors and down the line affect or even downregulate the kainate and glutamate receptors 1, implicated in nerve signal intensity.
Ultimately, sulbutiamine still needs a lot more research to understand the significance of its effects. What is currently established in research is that sulbutiamine has a marked effect on conditions like asthenia. 2
The consensus on Drugs-Forum.com 3 and Longecity 4 seem to be that long term usage is okay and may be preferable. The sources on Examine.com 5 also seem to point to long term usage.
How to take Sulbutiamine / Dosage
The original manufacturer of Sulbutiamine suggests doses of no more than 600 mg per day.
I typically take 100-200 mg spread out 2 or 3 times during the day, and this is how others tend to take it.
Because sulbutiamine is best absorbed with foods due to its lipophilic properties, you should take sulbutiamine after eating or after taking a fatty supplement like fish oil.
It can be taken in water but some may find the taste objectionable. Sulbutiamine capsules are available.
My experience with Sulbutiamine
Like PEA and Hordenine, I just ordered Sulbutiamine without knowing what to expect.
On my first time, I took a small dose — maybe 100 mg or so and didn’t notice anything outstanding. It’s just something that you notice to be good for you over time. I eventually upped my single doses to about 250 mg and began taking it daily.
On those rare days where I am exceptionally tired (due to not sleeping well or some other obstruction to my lifestyle) and haven’t had any special pick-me-ups, I really feel it when I haven’t been taking sulbutiamine.
On those same rare days I’m overcome with a sort of subtle fatigue or weakness that can’t be explained. It’s like there is no power in my muscles and it takes a while to get to normal functioning.
Sulbutiamine isn’t really stimulating to me in the sense of something like caffeine, but when taken in that rare fatigued condition, it’s like full control over my body returns to me. This may be related to the thiamine content itself rather than the dopaminergic effects.
Obviously this should be double blinded to be certain that it’s not placebo, but it’s something I notice has made a difference. When taking sulbutiamine I find it harder to use “I don’t have the energy” as an excuse not to do certain things.
In my time taking sulbutiamine, I have not noticed any “tolerance,” nor have I noticed “withdrawls” from stopping. However I will have to take it for a longer period of time to see how it works out for me.
Sulbutiamine is not a stimulant in the classical sense and may take a while before you see any real benefits or changes. Nonetheless, its reported effects on mental energy, mood and motivation may be worth investigating further. At approximately 50 cents per dose, it’s affordable enough if you’re looking to try something new.
References [ + ]
|1.||↑||PubMed – Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.|
|2.||↑||PubMed – Pharmacologic and therapeutic features of sulbutiamine.|
|3.||↑||Drugs Forum – Sulbutiamine, while awesome, not for the long term|
|4.||↑||Longecity – Sulbutiamine actually for the long term?|
|5.||↑||Examine.com – Sulbutiamine|