This post is going to be a shorter one as it’s something I still need to investigate for myself, but I recently learned a few interesting things relating to dopamine, serotonin and their roles in preventing or causing premature ejaculation. This one’s more notes and thoughts rather than a fully fledged post.
Can Mucuna Pruriens (Dopamine booster) Exacerbate Premature Ejaculation?
Based on my experience with it, I think that while it does increase libido, mucuna pruriens also does increase the likelihood of premature ejaculation. If you recall my brief review of it, I experienced a sudden bout of it where I hadn’t experienced it before.
Mucuna pruriens is a dopamine booster, meaning that while it increases libido, it also appears to lower the threshold for ejaculation, meaning you’ll be going from 0 to 60 a lot more quickly. This can be good or bad depending on your needs, but it’s mostly bad if you are already dealing with premature ejaculation and have no issues with libido otherwise.
The Role of Serotonin in Orgasm and Libido
It seems that people who take SSRIs tend to have a lowered libido, and/or they take forever to reach orgasm due to the effects of their medication.
This could be due to the way the body’s ability to break down serotonin is reduced by the SSRI medication. There is actually a medication on the market that originated as an SSRI antidepressant, dapoxetine1, which found application for premature ejaculation due to its fast action and metabolism compared to other SSRIs used for depression.
In theory, we could also increase our serotonin activity in the brain and have the same net effect.
The Drawbacks of Raising Serotonin
The obvious drawback of nonselectively increasing serotonin (in the case of taking 5-HTP for example) is that it has a tendency to become melatonin depending on light conditions, and it can also affect your mood.
Serotonin appears to act as a sort of counterbalance to dopamine, and raising serotonin means you lower dopamine in some cases, and lowering dopamine and raising serotonin can make one feel tranquil yet “drained.” It might be good for sex, but it might not be as good for going about your day.
A compromise of sorts: interacting with GABA receptors
In my experience, using something that interacts with the GABA receptors can help put off orgasm for a while, possibly because it decreases sensitivity.
Too much GABA interaction can cause some problems though, like the infamous “whiskey dick” one can get from drinking too much alcohol prior to sex, or “altered libido” as a side effect of being under the influence of pharmaceutical strength GABAergics like the benzodiazepene Xanax2
For some people, enough drinks to reach a mild to moderate buzz, or a small dose of something like phenibut may do the trick (See Chris from GLL’s page on phenibut for sex – Not work safe!).
- Theanine, while adequate for mild anxiousness, may be too mild for this purpose.
- Kava kava may have been helpful for sex in my experience, but may be too exotic for these purposes.
- Valerian is more mild and seems to be better suited as a sleep aid.
- Cannabis seems to work very well, but obviously its quality and legal status varies.
Practical solutions I will explore
For the future, I may explore some of the following in-depth, separately and/or together (being mindful of potential interactions and negative effects) to solve the problem of premature ejaculation:
- Phenibut (GABA agonist, strong)
- Picamilon (GABA agonist)
- Kratom (mu-opioid receptor agonist;3 noted side effect is “delayed ejaculation”)
- Kava Kava (GABA agonist)
- Valerian Root (GABA agonist)
- 5-HTP (Serotonin)
- St. John’s Wort (Serotonin receptor agonist)
- Tianeptine (new to me; strong, tricyclic antidepressant as a prescription drug in Europe – Be careful!)
Feel free to list any of your suggestions, opinions or explain a bit of your experiences in the comments below.